(Owner's Manual) 'If you are using a USB-B to USB-C adapter own a newer Apple computer, always plug the USB-C end of the adapter into a USB-C or Thunderbolt 3 (USB-C) port on your Mac first, and then connect the USB cable of your Axe-Fx III to the adapter.'

This parameter has been removed in firmware 20.02 and later. The size of the USB buffer used to be adjustable in the I/O menu. Requires OS X 10.6.8 for MIDI over USB, 10.9 for USB Audio. Mac – no driver required (class compliant). Windows – requires installing a USB driver. It's recommended to wait a little while, before launching the editor. The USB subsystem boots instantly on power on, it doesn't depend on the DSP, but it does need some time to settle down though. It also supports USB Audio and direct connection to iOS devices. It supports USB 2.0 to connect the unit to a computer, to run software editors and Fractal-Bot.

The Axe-Fx III has a dedicated 16-core, 500 MHz USB microcontroller. Support for these features differs per processor.

a connection method to transmit digital data between USB ports, for example to transfer presets to/from a computer, to run the editor, to transmit MIDI-over-USB, etc.

It's important to understand that USB can mean several things:

6.8 USB issues after the computer resumes from sleep mode.

Usb 2 vs usb 3 for audio